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Ing in an inpatient burn unit L. Koch, J. Jancik, H. Rhodes, E. Walter Hennepin County Medical Center, Minneapolis, USA Critical Care 2016, 20(Suppl 2):P117 Introductions: The incidence of venous thromboembolism (VTE) in acute burn patients has been reported to range from 0.4 -23 . [1] Standard enoxaparin prophylaxis dosing has been shown to provide anti-Xa levels below goal in a significant proportion of burn patients, resulting in a potential increase in thrombotic risk. [2] The objectives of this study were to evaluate the effectiveness of standard prophylaxis enoxaparin dosing within an inpatient burn unit and identify patient characteristics associated with lower initial anti-Xa levels. Methods: Patients admitted to the burn unit between November 2009 and July 2015 with an appropriately measured anti-Xa level were examined through retrospective chart review. Levels were considered appropriate if drawn 3-5 hours after at least three consecutive enoxaparin doses. Anti-Xa levels ranging from 0.1-0.4U/mL were considered to be within the goal prophylactic range. Patient demographics and injury data including age, sex, admission weight, and burn percentage of total body surface area ( TBSA) wereP118 Determination of optimal cut-off values of haemoglobin, platelet count and fibrinogen at 24 hours after injury associated with mortality in trauma PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/12711626 patients K. Maekawa1, M. Hayakawa1, S. Kushimoto2, A. Shiraishi3, H. Kato4, J. Sasaki5, H. Ogura6, T. Matauoka7, T. Uejima8, N. Morimura9, H. Ishikura10, A. Hagiwara11, M. Takeda12 1 Hokkaido University Hospital, Sapporo, Japan; 2Tohoku University Graduate School of Medicine, Sendai, Japan; 3Tokyo Medical and Dental University Hospital of Medicine, Tokyo, Japan; 4National Hospital Organization Disaster Medical Center, Tokyo, Japan; 5Keio University School of Medicine, Tokyo, Japan; 6Osaka University Graduate School of Medicine, Osaka, Japan; 7Rinku General Medical Center, Osaka, Japan; 8 Kinki University Faculty of Medicine, Osaka, Japan; 9Yokohama City University Graduate School of Medicine, Yokohama, Japan; 10Faculty of Medicine, Fukuoka University, Fukuoka, Japan; 11National Center For Global Health and Medicine, Tokyo, Japan; 12Tokyo Women's Medical University, Tokyo, Japan Critical ROCK-IN-2 Care 2016, 20(Suppl 2):P118 Introductions: The purpose of this study was to determine optimal cut-off values of haemoglobin, platelet count and fibrinogen at 24 hours after injury associated with mortality in trauma patients. Methods: We performed a retrospective analysis of patients survived over PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/22316373 24 hours after injury from J-OCTET (Japanese Observational study for Coagulation and Thrombolysis in Early Trauma) database. JOCTET was a retrospective multicenter study to investigate disorders of coagulation and thrombolysis in patients with severe trauma. Multivariable logistic regression models were developed to determine optimal cut-off values of hemoglobin, platelet count and fibrinogen at 24 hours after injury. We validated the models internally with bootstrapping to assess potential overfitting. Results: There were 722 trauma patients included, with median age of 57 years, median injury severity score of 22, median revised trauma score of 7.84, and an overall mortality of 6.5 . The optimal models associated with mortality were hemoglobin < 10.0 g/dL (c-statistic 0.77, 95 CI #12288;0.69-0.85), platelet count < 10.0x104 / L (0.80, 0.72-0.87), fibrinogen < 200 mg/dL (0.82, 0.72-0.92). After 200 cycles of bootstrappi.